Tadapox

Tadapox 80 mg from Centurion Laboratories Pvt. Ltd. contains tadalafil and dapoxetine.

Tadalafil is a selective inhibitor of PDE5. PDE5 is found in the smooth muscle of the corpus cavernosum, prostate, and bladder as well as in vascular and visceral smooth muscle, skeletal muscle, urethra, platelets, kidney, lung, cerebellum, heart, liver, testis, seminal vesicle, and pancreas.

Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP. Tadalafil inhibits PDE5. Because sexual stimulation is required to initiate the local release of nitric oxide, the inhibition of PDE5 by tadalafil has no effect in the absence of sexual stimulation.

Tadapox 80 mg administered to healthy men produced no significant difference compared to placebo in supine systolic and diastolic blood pressure and in standing systolic and diastolic blood pressure. In addition, there was no significant effect on heart rate.

Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI) marketed for the treatment of premature ejaculation in men. Human ejaculation is primarily mediated by the sympathetic nervous system. The ejaculatory pathway originates from a spinal reflex centre, mediated by the brain stem, which is influenced initially by a number of nuclei in the brain (medial preoptic and paraventricular nuclei).

The mechanism of action of dapoxetine in premature ejaculation is presumed to be linked to the inhibition of neuronal reuptake of serotonin and the subsequent potentiation of the neurotransmitter's action at pre– and postsynaptic receptors.

Dapoxetine inhibits the ejaculatory expulsion reflex by acting at a supraspinal level within the lateral paragigantocellular nucleus (LPGi). Postganglionic sympathetic fibers that innervate the seminal vesicles, vas deferens, prostate, bulbourethral muscles and bladder neck cause them to contract in a coordinated fashion to achieve ejaculation. Dapoxetine has the ability to lengthen the time between sexual arousal and climax.

Do not take more than one dose of Tadapox 80 mg per day.

It is recommended that tablets be taken with at least one full glass of water. Always talk to your doctor before taking ANY medication for erectile dysfunction (ED) or premature ejaculation. Some erectile dysfunction medications are not suitable for men with certain medical conditions, and your doctor can advise you on an alternative. Read contraindications. Call your doctor immediately if you experience dizziness or feel nauseous during sexual activity, or develop pain, numbness, tingling in your chest, arms, neck, or jaw. Seek emergency treatment if an erection lasts more than 4 hours.

Do not take Tadapox 80 mg if you are also taking a nitrate drug (such as nitroglycerin or isosorbide dinitrate/mononitrate) for chest pain or heart problems.

Do not take Tadapox 80 mg with recreational drugs such as "poppers". Taking these substances together can cause a sudden and dangerous drop in blood pressure.

Do not take Tadapox 80 mg if you are also taking: 

• antiepileptics
• antidepressants
• antipsychotics
• anxiolytics
• sedative hypnotics

Do not take Tadapox 80 mg with recreational drugs such as: ketamine, methylenedioxymethamphetamine (MDMA), lysergic acid diethylamide (LSD).

Always buy your medications from a reputable supplier as there are a lot of counterfeit products on the market.

Certain lifestyle and psychological factors, such as smoking, drinking, and stress, can impact on premature ejaculation and erectile dysfunction. Eliminating these may also help improve the ejaculation and erection. for example:

• staying more active
• losing weight if you are overweight
• reducing alcohol intake
• stopping smoking and reducing stress

Never take other erectile dysfunction or premature ejaculation medications at the same time as taking Tadapox 80 mg.

Seek urgent medical advice if an allergic reaction, sudden vision loss or painful erections lasting more than four hours occur.

Drinking alcohol after taking Tadapox 80 mg may lower blood pressure and decrease sexual performance.

Along with its needed effects, Tadapox 80 mg may cause some unwanted effects.

Although not all of these side effects may occur, if they do occur they may need medical attention.

See below for a comprehensive list of commonly reported side effects.

Most common side effects

• headache
• dyspepsia
• back pain
• blocked nose
• dryness in eyes
• dizziness
• nausea
• flushing
• anxiety
• agitation
• restlessness
• insomnia
• abnormal dreams
• libido decreased
• vision blurred
• diarrhoea
• vomiting
• blood pressure increased

If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Many people using this medication do not have serious side effects.

Less common side effects

The following side effects of Tadapox 80 mg may occur that usually do not need medical attention. These side effects are not dangerous and may normally diminish as your body adjusts to the medicine. Patients presenting with these side effects generally do not need to stop taking Tadapox 80 mg.

Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• myalgia
• nasal congestion
• facial flushing and flushing
• pain in limb
• upper respiratory tract infection
• diarrhea
• nasal congestion
• urinary tract infection
• light sensitivity
• ringing in ears
• slight blurred vision
• slight blueness in vision

Serious rare side effects

Although serious side effects are rare, if you experience any the following serious side effects, stop taking Tadapox 80 mg and seek emergency medical care immediately.

• chest pain
• dizziness during sex
• erection longer than 4 hours (Priapism)
• severe decrease or loss of vision
• severe decrease or loss of hearing
• shortness of breath or trouble breathing

If this serious problem occurs, stop taking Tadapox 80 mg and get medical help right away. You have a slightly greater chance of developing NAION if you have heart disease, diabetes, high cholesterol, certain other eye problems ("crowded disk"), high blood pressure, if you are over 50, or if you smoke.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including:

• rash
• itching/swelling (especially of the face/tongue/throat)
• severe dizziness
• trouble breathing

Patients taking the following medicine types should NOT take Tadapox 80 mg:

• nitroglycerin medicines
• nitroprusside medicines
• amyl nitrate (recreationally known as poppers)
• guanylate cyclase (GC) stimulators
• alpha-blockers (caution is advised when PDE5 inhibitors are coadministered with alpha-blockers)
• organ donor recipient medicines
• SSRI in combination with a monoamine oxidase inhibitor (MAOI)
• recreational drugs (ketamine, methylenedioxymethamphetamine (MDMA) and lysergic acid diethylamide (LSD))
• thioridazine
• serotonergic medicinal/herbal products (including MAOIs, L-tryptophan, triptans, tramadol, linezolid, SSRIs, SNRIs, lithium and St. John's Wort
• CNS active medicinal products (e.g., antiepileptics, antidepressants, antipsychotics, anxiolytics, sedative hypnotics)
• potent CYP3A4 inhibitors
• potent CYP2D6 inhibitors
• azole antifungal medicines taken orally (topical creams for treatment of candida/ thrush are safe)
• serious hypersensitivity to tadalafil
• antihypertensives
• antacids
• alcohol

Both alcohol and tadalafil, act as mild vasodilators. When mild vasodilators are taken in combination, blood-pressure-lowering effects of each individual compound may be increased. Substantial consumption of alcohol in combination with Tadapox 80 mg can increase the potential for orthostatic signs and symptoms.

Tadapox 80 mg is not suitable for everyone.

Before taking Tadapox 80 mg, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Patients under treatment for the following conditions; or any ongoing managed condition, should consult their doctor prior to taking Tadapox 80 mg:

• heart related & cardiovascular diseases including aortic stenosis, idiopathic hypertrophic subaortic stenosis and general ventricular outflow obstruction
• stroke within the last 6 months
• myocardial infarction (heart attack) within the last 90 day
• uncontrolled arrhythmias
• cardiac failure or coronary artery disease causing unstable angina
• blood pressure related diseases including hypertension & hypotension and patients with severely impaired autonomic control of blood pressure
• resting hypotension (low blood pressure) of (BP <90/50)
• resting hypertension (high blood pressure) of (BP >170/110)
• retinitis pigmentosa (genetic disease of the retina)
• sickle cell or other related anaemias
• kidney disease
• liver disease
• bleeding disorders
• active stomach ulcers
• HIV (specifically on treatment with protease inhibitors)
• organ donor recipients
• mania/hypomania or bipolar disorder

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Patients should be advised not to use Tadapox 80 mg in combination with recreational drugs. Recreational drugs with serotonergic activity such as ketamine, methylenedioxymethamphetamine (MDMA) and lysergic acid diethylamide (LSD) may lead to potentially serious reactions if combined with Tadapox 80 mg. These reactions include, but are not limited to, arrhythmia, hyperthermia, and serotonin syndrome. Use of Tadapox 80 mg with recreational drugs with sedative properties such as narcotics and benzodiazepines may further increase somnolence and dizziness. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call doctor or emergency immediately.

Treatments for erectile dysfunction, including Tadapox 80 mg, should not be used in men for whom sexual activity is inadvisable as a result of their underlying cardiovascular status. Patients who experience symptoms upon initiation of sexual activity should be advised to refrain from further sexual activity and seek immediate medical attention.

As with other PDE5 inhibitors, tadalafil has mild systemic vasodilatory properties that may result in transient decreases in blood pressure. Patients with severely impaired autonomic control of blood pressure may be particularly sensitive to the actions of vasodilators, including PDE5 inhibitors. There have been rare reports of prolonged erections greater than 4 hours and priapism (painful erections greater than 6 hours in duration) for this class of compounds.

Priapism, if not treated promptly, can result in irreversible damage to the erectile tissue. Patients who have an erection lasting greater than 4 hours, whether painful or not, should seek emergency medical attention.

Centurion Laboratories Pvt. Ltd.

The origins of this pharmaceutical company date back to 2006 when it was founded in the Indian state of Gujarat. Centurion Laboratories' vision is to become one of the largest pharmaceutical manufacturers in the country. However, after 2015, the company began to focus on making generic drugs as well. Centurion Laboratories makes generic drugs of known drugs to help men with erectile dysfunction and premature ejaculation. The best known is probably the generic Viagra, which is sold in our e-shop as Cenforce. Another popular medicine by Centurion Laboratories to treat erectile dysfunction is Tadapox. Our customers have also had positive experiences with medicine to treat erectile dysfunction and premature ejaculation like D-Force, or Vidalista.